Ordering and
Acquiring CINQAIR® (reslizumab) Injection
CINQAIR® can be ordered from one of our Authorized Specialty Distributors (Buy & Bill) or, subject to a patient’s health plan requirements, CINQAIR® may also be acquired from a specialty pharmacy.
Buy & Bill
These Authorized Specialty Distributors are the exclusive suppliers of CINQAIR® .
Contact the individual specialty distributor for current pricing.
Specialty Pharmacy
In situations where a treatment provider prefers to acquire CINQAIR® via a speciality pharmacy, or when a patient's health plan mandates a specialty pharmacy:
Select specialty pharmacy as the preferred acquisition method on the Prescription and Service Request Form. Teva Support Solutions® will confirm specialty pharmacy requirements.
Teva Support Solutions® will refer the prescription to the specific specialty pharmacy to fulfill and ship CINQAIR® to a site of administration if the patient’s health plan requirements are met.
Note: The specialty pharmacy may contact the prescriber to request additional information, including a request to re-send a CINQAIR® prescription directly to the specialty pharmacy.
Reimbursement
Once the patient receives their treatment, submit a reimbursement claim to the patient’s health insurance plan for the cost of medication and infusion administration.
If using a specialty pharmacy, submit a reimbursement claim for the infusion administration only.
Download the At-a-Glance Guide to Codes for CINQAIR® for support in completing a reimbursement claim.
Get connected to Teva Support Solutions®
Call 1-844-838-2211 , Monday–Friday, 9AM–7PM ET
INDICATIONS AND USAGE
CINQAIR (reslizumab) Injection is an interleukin-5 antagonist monoclonal antibody (IgG4 kappa) indicated for add-on maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype.
Limitations of Use: CINQAIR is not indicated for:
treatment of other eosinophilic conditions
relief of acute bronchospasm or status asthmaticus
IMPORTANT SAFETY INFORMATION
WARNING: ANAPHYLAXIS
Anaphylaxis has been observed with CINQAIR infusion in 0.3% of patients in placebo-controlled clinical studies. Anaphylaxis was reported as early as the second dose of CINQAIR.
Anaphylaxis can be life-threatening. Patients should be observed for an appropriate period of time after CINQAIR administration by a healthcare professional prepared to manage anaphylaxis. Discontinue CINQAIR immediately if the patient experiences signs or symptoms of anaphylaxis.
IMPORTANT SAFETY INFORMATION (continued)
CONTRAINDICATIONS
CINQAIR is contraindicated in patients who have known hypersensitivity to reslizumab or any of its excipients.
WARNINGS AND PRECAUTIONS
Acute Asthma Symptoms or Deteriorating Disease: CINQAIR should not be used to treat acute asthma symptoms or acute exacerbations. Do not use CINQAIR to treat acute bronchospasm or status asthmaticus. Patients should seek medical advice if their asthma remains uncontrolled or worsens after initiation of treatment with CINQAIR.Malignancy: In placebo-controlled clinical studies, 6/1028 (0.6%) patients receiving 3 mg/kg CINQAIR had at least 1 malignant neoplasm reported compared to 2/730 (0.3%) patients in the placebo group. The observed malignancies in CINQAIR-treated patients were diverse in nature and without clustering of any particular tissue type. The majority of malignancies were diagnosed within less than six months of exposure to CINQAIR.Reduction of Corticosteroid Dosage: No clinical studies have been conducted to assess reduction of maintenance corticosteroid dosages following administration of CINQAIR. Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with CINQAIR. Reductions in corticosteroid dose, if appropriate, should be gradual and performed under the supervision of a physician. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.Parasitic (Helminth) Infection: Eosinophils may be involved in the immunological response to some helminth infections. Treat patients with pre-existing helminth infections before initiating CINQAIR. If patients become infected while receiving treatment with CINQAIR and do not respond to anti-helminth treatment, discontinue treatment with CINQAIR until infection resolves.
ADVERSE REACTIONS
Adverse reactions that occurred at ≥2% incidence and more commonly than in the placebo group included 1 event: oropharyngeal pain (2.6% vs. 2.2%).
Elevated baseline creatine phosphokinase (CPK) was more frequent in patients randomized to CINQAIR (14%) versus placebo (9%). Transient CPK elevations in patients with normal baseline CPK values were observed more frequently with CINQAIR (20%) versus placebo (18%) during routine laboratory assessments.
Myalgia was reported in 1% (10/1028) of patients in the CINQAIR 3 mg/kg group compared to 0.5% (4/730) of patients in the placebo group.
Immunogenicity: In placebo-controlled studies, a treatment-emergent anti-reslizumab antibody response developed in 53/983 (5.4%) of CINQAIR-treated patients (3 mg/kg). The antibody responses were of low titer and often transient. There was no detectable impact of the antibodies on the clinical pharmacokinetics, pharmacodynamics, clinical efficacy, and safety of CINQAIR.
Please see full Prescribing Information ® .
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Get connected to Teva Support Solutions®
Call 1-844-838-2211 , Monday–Friday, 9AM–7PM ET
Find out more about CINQAIR® at CINQAIR.com
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